Objective

The purpose of this study was to investigate the HCRTR2 gene variants rs3122156, rs2653342, and rs2653349 in a large homogenous Swedish case‐control cohort in order to further evaluate the possible contribution of HCRTR2 to cluster headache.

Background

Cluster headache is a severe neurovascular disorder and the pathophysiology is not yet fully understood.… Read More...

Introduction

Headache attributed to aeroplane travel (AH) is one of the new nosological entries in the International Classification of Headache Disorders (ICHD) 3 beta.

Materials and Methods

This study retraces the history of headache related to flight, from the initial description to the modern reports, on the basis of original sources.… Read More...

Background

Structural damage or demyelization of the sphenopalatine ganglion may cause sphenopalatine neuralgia (SN). The current International Classification of Headache Disorders, third edition (ICHD‐3) regards SN as a phenotype of cluster headache. Whether SN is an independent neuralgia entity has been debated for years.… Read More...

Objective

To assess the effectiveness and adverse effects of acute cluster headache medications in a large international sample, including recommended treatments such as oxygen, commonly used medications such as opioids, and emerging medications such as intranasal ketamine. Particular focus is paid to a large subset of respondents 65 years of age or older.… Read More...

Genetic mutations of sporadic hemiplegic migraine (SHM) are mostly unknown. SHM pathophysiology relies on cortical spreading depression (CSD), which might be responsible for ischemic brain infarction. Cystic fibrosis (CF) is caused by a monogenic mutation of the chlorine transmembrane conductance regulator (CFTR), possibly altering brain excitability.… Read More...

Objective

This study was conducted to investigate sex differences in the prevalence and clinical presentation of migraine and probable migraine in a general population‐based sample.

Background

While there is research on sex differences in clinical characteristics and their impact on migraine headache, only few studies have investigated sex differences in probable migraine in population‐based settings.… Read More...

Cephalalgia, Ahead of Print.