Carmen Fourier, Caroline Ran, Anna Steinberg, Christina Sjöstrand, Elisabet Waldenlind, Andrea Carmine Belin January 17, 2019


The purpose of this study was to investigate the HCRTR2 gene variants rs3122156, rs2653342, and rs2653349 in a large homogenous Swedish case‐control cohort in order to further evaluate the possible contribution of HCRTR2 to cluster headache.


Cluster headache is a severe neurovascular disorder and the pathophysiology is not yet fully understood.… Read More...

Wei He, Yixin Zhang, Ting Long, Qi Pan, Shanshan Zhang, Jiying Zhou January 12, 2019


Structural damage or demyelization of the sphenopalatine ganglion may cause sphenopalatine neuralgia (SN). The current International Classification of Headache Disorders, third edition (ICHD‐3) regards SN as a phenotype of cluster headache. Whether SN is an independent neuralgia entity has been debated for years.… Read More...

Stuart M. Pearson, Mark J. Burish, Robert E. Shapiro, Yuanqing Yan, Larry I. Schor January 11, 2019


To assess the effectiveness and adverse effects of acute cluster headache medications in a large international sample, including recommended treatments such as oxygen, commonly used medications such as opioids, and emerging medications such as intranasal ketamine. Particular focus is paid to a large subset of respondents 65 years of age or older.… Read More...

Valentina Mancini, Giulio Mastria, Viviana Frantellizzi, Patrizia Troiani, Stefania Zampatti, Stefania Carboni, Emiliano Giardina, Rosa Campopiano, Stefano Gambardella, Federica Turchi, Barbara Petolicchio, Massimiliano Toscano, Mauro Liberatore, Alessandro Viganò, Vittorio Di Piero January 9, 2019

Genetic mutations of sporadic hemiplegic migraine (SHM) are mostly unknown. SHM pathophysiology relies on cortical spreading depression (CSD), which might be responsible for ischemic brain infarction. Cystic fibrosis (CF) is caused by a monogenic mutation of the chlorine transmembrane conductance regulator (CFTR), possibly altering brain excitability.… Read More...

Tae‐Jin Song, Soo‐Jin Cho, Won‐Joo Kim, Kwang Ik Yang, Chang‐Ho Yun, Min Kyung Chu January 9, 2019


This study was conducted to investigate sex differences in the prevalence and clinical presentation of migraine and probable migraine in a general population‐based sample.


While there is research on sex differences in clinical characteristics and their impact on migraine headache, only few studies have investigated sex differences in probable migraine in population‐based settings.… Read More...

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