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traumatic brain injury

Traumatic brain injury
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis

by myneuronews January 10, 2026

by myneuronews January 10, 2026

Study Overview The investigation centers on the complex interplay between microglial activation and the body’s …

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Traumatic brain injury
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury

by myneuronews January 10, 2026

by myneuronews January 10, 2026

Study Overview This investigation focuses on the effects of N-stearidonoylethanolamine (NSE) in addressing synaptic deficits …

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Traumatic brain injury
Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review

by myneuronews January 10, 2026

by myneuronews January 10, 2026

Incretin Mimetics Mechanism of Action Incretin mimetics are agents that are designed to mimic the …

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Traumatic brain injury
Mechanisms and products implicated in mild traumatic brain injury among children aged 0-5 years old presenting to Canadian emergency departments

by myneuronews January 9, 2026

by myneuronews January 9, 2026

Mechanisms of Mild Traumatic Brain Injury Mild traumatic brain injury (mTBI) occurs when a child’s …

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Traumatic brain injury
Potential Role of Serum Cytokines and Chemokines as Biomarkers of Injury Severity and Functional Outcomes Following Pediatric Traumatic Brain Injury

by myneuronews January 9, 2026

by myneuronews January 9, 2026

Study Overview The research focuses on understanding how specific proteins called cytokines and chemokines, which …

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Traumatic brain injury
CCL5/RANTES signaling in inflammation dysregulation after mild traumatic brain injury

by myneuronews January 8, 2026

by myneuronews January 8, 2026

CCL5/RANTES Role in Brain Injury CCL5, also known as RANTES (Regulated upon Activation, Normal T …

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Traumatic brain injury
Repetitive mild traumatic brain injury with the closed-head impact model of engineered rotational acceleration (CHIMERA) promotes tau pathology in tau transgenic mice and its propagation in brains injected with tau fibrils

by myneuronews January 8, 2026

by myneuronews January 8, 2026

Study Overview This study investigates the effects of repetitive mild traumatic brain injury (rmTBI) on …

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Traumatic brain injury
A Longitudinal Study of Error-Related Neural Responses in Adolescents Following Mild Traumatic Brain Injury (mTBI)

by myneuronews January 8, 2026

by myneuronews January 8, 2026

Study Overview The study investigates the neural responses associated with error monitoring in adolescents who …

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Traumatic brain injury
Author’s Reply to: Comment on “Orthostatic Tachycardia in Children With and Without Persisting Postconcussion Symptoms Following Mild Traumatic Brain Injury: A Prospective Controlled Study”

by myneuronews January 8, 2026

by myneuronews January 8, 2026

Study Overview The research focused on comparing the presence and severity of orthostatic tachycardia in …

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Traumatic brain injury
Stability of salivary microRNA measures across an NCAA Division I football season: Implications for microRNA as a biomarker of concussion

by myneuronews January 8, 2026

by myneuronews January 8, 2026

Study Overview The focus of this research is on salivary microRNAs and their stability throughout …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]